Manto Tshabalala-Msimang, South African physician and politician, 22nd South African Minister of Health (b. 1940)
Mantombazana "Manto" Edmie Tshabalala-Msimang (née Mali; 9 October 1940 – 16 December 2009) was a South African politician. She was Deputy Minister of Justice from 1996 to 1999 and served as Minister of Health from 1999 to 2008 under President Thabo Mbeki. She also served as Minister in the Presidency under President Kgalema Motlanthe from September 2008 to May 2009.

Her emphasis on treating South Africa's AIDS epidemic with easily accessible vegetables such as African potato, garlic and beetroot, rather than with antiretroviral medicines, was the subject of local and international criticism. These policies led to the deaths of over 300,000 infected South Africans.