Pan Am Flight 214 was a scheduled flight of Pan American World Airways from Isla Verde International Airport in San Juan, Puerto Rico, to Friendship Airport in Baltimore and Philadelphia International Airport. On December 8, 1963, the Boeing 707-121 serving the flight crashed near Elkton, Maryland, while flying from Baltimore to Philadelphia, after being hit by lightning. All 81 occupants of the plane were killed. The crash was Pan Am's first fatal accident with the 707, which it had introduced to its fleet five years earlier.

An investigation by the Civil Aeronautics Board concluded that the cause of the crash was a lightning strike that had ignited fuel vapors in one of the aircraft's fuel tanks, causing an explosion that destroyed one of the wings. The exact manner of ignition was never determined, but the investigation yielded information about how lightning can damage aircraft, leading to new safety regulations. The crash also spawned research into the safety of various types of aviation fuel and into methods of reducing dangerous fuel-tank vapors.