The Hama Massacre (Arabic: مجزرة حماة), or Hama Uprising, occurred in February 1982 when the Syrian Arab Army and the Defense Companies, under orders of the country's president Hafez al-Assad, besieged the town of Hama for 27 days in order to quell an uprising by the Muslim Brotherhood against al-Assad's government. The massacre, carried out by the Syrian Army under commanding General Rifaat al-Assad, effectively ended the campaign begun in 1976 by Sunni Muslim groups, including the Muslim Brotherhood, against the government.

Initial diplomatic reports from Western countries stated that 1,000 were killed. Subsequent estimates vary, with the lower estimates claiming that at least 2,000 Syrian citizens were killed, while others put the number at 20,000 (Robert Fisk) or 40,000 (Syrian Human Rights Committee). About 1,000 Syrian soldiers were killed during the operation, and large parts of the old city were destroyed. The attack has been described as one of the "deadliest acts by any Arab government against its own people in the modern Middle East". According to the Syrian opposition, the vast majority of the victims were civilians.