UPMC Mercy is a main hospital facility of the University of Pittsburgh Medical Center (UPMC) and is located in the Uptown section of the city of Pittsburgh, Pennsylvania, adjacent to Duquesne University, and a few blocks from the PPG Paints Arena and downtown Pittsburgh. It is the first chartered hospital to have been founded in the city of Pittsburgh and it is also the first hospital in the world to have been established by the Sisters of Mercy. It is also the first teaching hospital in the region, accepting residents to teaching positions beginning in 1848, one year after opening its doors.

In January 2008, Mercy Hospital merged with Pittsburgh health care giant UPMC, taking on its current name UPMC Mercy. UPMC Mercy remains Pittsburgh's only Catholic hospital that provides a full breadth of specialized services.