The Major League Baseball All-Star Game, also known as the "Midsummer Classic", is an annual professional baseball game sanctioned by Major League Baseball (MLB) and contested between the all-stars from the American League (AL) and National League (NL). All-Stars are selected by fans for starting fielders, by managers for pitchers, and by managers and players for reserves.

The game is usually played on the second or third Tuesday in July, and is meant to mark the symbolic halfway point of the MLB season (though not the mathematical halfway point, which, for most seasons, falls within the previous calendar week). Both leagues share an All-Star break, with no regular-season games scheduled from the day before through two days after the All-Star Game, with the exception of a single Thursday night game starting in the 2018 season. Some additional events and festivities associated with the game take place each year close to and during this break in the regular season.

No official MLB All-Star Games were held in 1945 and 2020, and no official selection of players took place, due to World War II travel restrictions and the COVID-19 pandemic, respectively. Two All-Star Games were held each season from 1959 to 1962. The most recent All-Star Game was held on July 13, 2021, at Coors Field in Denver, home of the NL's Colorado Rockies; it was originally scheduled to be held in Atlanta until Major League Baseball announced in April 2021 that it would relocate the game in protest of new voting rights restrictions in that state.