The Black Death (also known as the Pestilence, the Great Mortality or simply, the Plague) was a bubonic plague pandemic occurring in Afro-Eurasia from 1346 to 1353. It is the most fatal pandemic recorded in human history, causing the death of 75200 million people in Eurasia and North Africa, peaking in Europe from 1347 to 1351. Bubonic plague is caused by the bacterium Yersinia pestis spread by fleas, but it can also take a secondary form where it is spread person-to-person contact via aerosols causing septicaemic or pneumonic plagues.The Black Death was the beginning of the second plague pandemic. The plague created religious, social and economic upheavals, with profound effects on the course of European history.

The origin of the Black Death is disputed. The pandemic originated either in Central Asia or East Asia but its first definitive appearance was in Crimea in 1347. From Crimea, it was most likely carried by fleas living on the black rats that travelled on Genoese ships, spreading through the Mediterranean Basin and reaching North Africa, Western Asia, and the rest of Europe via Constantinople, Sicily, and the Italian Peninsula. There is evidence that once it came ashore, the Black Death mainly spread person-to-person as pneumonic plague, thus explaining the quick inland spread of the epidemic, which was faster than would be expected if the primary vector was rat fleas causing bubonic plague. In 2022, it was discovered that there was a sudden surge of deaths in what is today Kyrgyzstan from the Black Death in the late 1330s; when combined with genetic evidence, this implies that the initial spread may not have been due to Mongol conquests in the 13th century, as previously speculated.The Black Death was the second great natural disaster to strike Europe during the Late Middle Ages (the first one being the Great Famine of 13151317) and is estimated to have killed 30 percent to 60 percent of the European population, as well as about one-third of the population of the Middle East. The plague might have reduced the world population from c.475 million to 350375 million in the 14th century. There were further outbreaks throughout the Late Middle Ages and, with other contributing factors (the Crisis of the Late Middle Ages), the European population did not regain its level in 1300 until 1500. Outbreaks of the plague recurred around the world until the early 19th century.

Pope Clement VI (Latin: Clemens VI; 1291 – 6 December 1352), born Pierre Roger, was head of the Catholic Church from 7 May 1342 to his death in 1352. He was the fourth Avignon pope. Clement reigned during the first visitation of the Black Death (1348–1350), during which he granted remission of sins to all who died of the plague.

Roger steadfastly resisted temporal encroachments on the Church's ecclesiastical jurisdiction and, as Clement VI, entrenched French dominance of the Church and opened its coffers to enhance the regal splendour of the Papacy. He recruited composers and music theorists for his court, including figures associated with the then-innovative Ars Nova style of France and the Low Countries.