Lucrezia Borgia, Italian wife of Alfonso I d'Este, Duke of Ferrara (b. 1480)
Lucrezia Borgia (Italian pronunciation: [luˈkrɛttsja ˈbɔrdʒa]; Valencian: Lucrècia Borja [luˈkrɛsia ˈbɔɾdʒa]; 18 April 1480 – 24 June 1519) was a Spanish-Italian noblewoman of the House of Borgia who was the daughter of Pope Alexander VI and Vannozza dei Cattanei. She reigned as the Governor of Spoleto, a position usually held by cardinals, in her own right.

Her family arranged several marriages for her that advanced their own political position including Giovanni Sforza, Lord of Pesaro and Gradara, Count of Catignola; Alfonso of Aragon, Duke of Bisceglie and Prince of Salerno; and Alfonso I d'Este, Duke of Ferrara. Tradition has it that Alfonso of Aragon was an illegitimate son of the King of Naples and that her brother Cesare Borgia may have had him murdered after his political value waned.

Rumors about her and her family cast Lucrezia as a femme fatale, a role in which she has been portrayed in many artworks, novels and films.