The Tuscarora War was fought in North Carolina from September 10, 1711 until February 11, 1715 between the Tuscarora people and their allies on one side and European American settlers, the Yamassee, and other allies on the other. This was considered the bloodiest colonial war in North Carolina. The Tuscarora signed a treaty with colonial officials in 1718 and settled on a reserved tract of land in Bertie County, North Carolina. The war incited further conflict on the part of the Tuscarora and led to changes in the slave trade of North and South Carolina.

The first successful settlement of North Carolina began in 1653. The Tuscarora lived in peace with the settlers for more than 50 years, while nearly every other colony in America was involved in some conflict with Native Americans. Most of the Tuscarora migrated north to New York after the war, where they joined the Five Nations of the Iroquois Confederacy as the sixth nation.