Pope Alexander VI (Italian: Alessandro VI; born Rodrigo de Borja; Valencian: Roderic Llanol i de Borja [roei ansl i e bda]; Spanish: Rodrigo Lanzol y de Borja [roio lanol i e oxa]; 1431 18 August 1503) was head of the Catholic Church and ruler of the Papal States from 11 August 1492 until his death in 1503.

Born into the prominent Borgia family in Xtiva under the Crown of Aragon (now Spain), Rodrigo studied law at the University of Bologna. He was ordained deacon and made a cardinal in 1456 after the election of his uncle as Pope Callixtus III, and a year later he became vice-chancellor of the Catholic Church. He proceeded to serve in the Curia under the next four popes, acquiring significant influence and wealth in the process. In 1492, Rodrigo was elected pope, taking the name Alexander VI.

Alexander's papal bulls of 1493 confirmed or reconfirmed the rights of the Spanish crown in the New World following the finds of Christopher Columbus in 1492. During the second Italian war, Alexander VI supported his son Cesare Borgia as a condottiero for the French king. The scope of his foreign policy was to gain the most advantageous terms for his family.Alexander is considered one of the most controversial of the Renaissance popes, partly because he acknowledged fathering several children by his mistresses. As a result, his Italianized Valencian surname, Borgia, became a byword for libertinism and nepotism, which are traditionally considered as characterizing his pontificate. On the other hand, two of Alexander's successors, Sixtus V and Urban VIII, described him as one of the most outstanding popes since Saint Peter.

Cesare Borgia (Italian pronunciation: [ˈtʃeːzare ˈbɔrdʒa, ˈtʃɛː-]; Valencian: Cèsar Borja [ˈsɛzaɾ ˈbɔɾdʒa]; Spanish: César Borja [ˈθesaɾ ˈβoɾxa]; 13 September 1475 – 12 March 1507) was an Italian cardinal and condottiero (mercenary leader) of Aragonese (Spanish) origin, whose fight for power was a major inspiration for The Prince by Niccolò Machiavelli. He was an illegitimate son of Pope Alexander VI and member of the Spanish-Aragonese House of Borgia.After initially entering the church and becoming a cardinal on his father's election to the Papacy, he became, after the death of his brother in 1498, the first person to resign a cardinalate. He served as a condottiero for King Louis XII of France around 1500, and occupied Milan and Naples during the Italian Wars. At the same time he carved out a state for himself in Central Italy, but after his father's death he was unable to retain power for long. According to Machiavelli, this was not due to a lack of foresight, but his error in creating a new pope.