USS Sailfish (SS-192), was a US Sargo-class submarine, originally named Squalus. As the Squalus, the submarine sank off the coast of New Hampshire during test dives on 23 May 1939. The sinking drowned 26 crew members, but an ensuing rescue operation, using the McCann Rescue Chamber for the first time, saved the lives of the remaining 33 aboard. The submarine was salvaged in late 1939 and decommissioned.

The submarine was recommissioned as the Sailfish in May 1940, and conducted numerous patrols in the Pacific War during World War II, earning nine battle stars. She was decommissioned in October 1945 and later scrapped; the conning tower remains on display at Portsmouth Naval Shipyard in Kittery, Maine.