The Great Appalachian Storm of November 1950 was a large extratropical cyclone which moved through the Eastern United States, causing significant winds, heavy rainfall east of the Appalachian Mountains, and blizzard conditions along the western slopes of the mountains. Hurricane-force winds, peaking at 110 miles per hour (180 km/h) in Concord, New Hampshire, and 160 mph (260 km/h) in the highlands of New England, disrupted power to 1 million customers during the event.

In all, the storm impacted 22 states, killing 383 people, injuring over 160, and causing $66.7 million in damage (equivalent to $717,000,000 in 2020). U.S. insurance companies paid out more money to their policy holders for damage resulting from the cyclone than for any previous storm or hurricane at the time. The cyclone is also one of only twenty-six storms to rank as a Category 5 on the Regional Snowfall Index.Termed, the "Storm of the Century".