Several planned missions of the Apollo crewed Moon landing program of the 1960s and 1970s were canceled for a variety of reasons, including changes in technical direction, the Apollo 1 fire, hardware delays, and budget limitations. After the landing by Apollo 12, Apollo 20, which would have been the final crewed mission to the Moon, was canceled to allow Skylab to launch as a "dry workshop" (assembled on the ground in an unused S-IVB Saturn IB second stage). The next two missions, Apollos 18 and 19, were later canceled after the Apollo 13 incident and further budget cuts. Two Skylab missions also ended up being canceled. Two complete Saturn Vs ended up going unused and are currently on display in the United States.

The National Aeronautics and Space Administration (NASA ) is an independent agency of the U.S. federal government responsible for the civilian space program, as well as aeronautics and space research.NASA was established in 1958, succeeding the National Advisory Committee for Aeronautics (NACA). The new agency was to have a distinctly civilian orientation, encouraging peaceful applications in space science. Since its establishment, most US space exploration efforts have been led by NASA, including the Apollo Moon landing missions, the Skylab space station, and later the Space Shuttle. NASA is supporting the International Space Station and is overseeing the development of the Orion spacecraft, the Space Launch System, Commercial Crew vehicles, and the planned Lunar Gateway space station. The agency is also responsible for the Launch Services Program, which provides oversight of launch operations and countdown management for uncrewed NASA launches.

NASA's science is focused on better understanding Earth through the Earth Observing System; advancing heliophysics through the efforts of the Science Mission Directorate's Heliophysics Research Program; exploring bodies throughout the Solar System with advanced robotic spacecraft such as New Horizons; and researching astrophysics topics, such as the Big Bang, through the Great Observatories and associated programs.