José Francisco Ruiz Massieu, Mexican lawyer and politician, 6th Governor of Guerrero (b. 1946)
José Francisco Ruiz Massieu (July 22, 1946 – September 28, 1994) was a Mexican political figure. He was governor of Guerrero from 1987 to 1993. He then served as the secretary-general of the Institutional Revolutionary Party (PRI) in 1994. His term ended with his assassination.

José Francisco Ruiz Massieu, the brother-in-law of then-President of Mexico Carlos Salinas, was due to become the PRI majority leader in the Chamber of Deputies. That changed on the morning of September 28, 1994, when he was murdered by a gunman, 28-year-old Daniel Aguilar Treviño, just outside Hotel Casa Blanca, located at Lafragua street crossing Paseo de la Reforma, an avenue in the center of Mexico City. The incident occurred while Ruiz Massieu was boarding his vehicle after attending a PRI party meeting held at Casa Blanca.