Mariner 10 was an American robotic space probe launched by NASA on 3 November 1973, to fly by the planets Mercury and Venus. It was the first spacecraft to perform flybys of multiple planets.Mariner 10 was launched approximately two years after Mariner 9 and was the last spacecraft in the Mariner program. (Mariner 11 and Mariner 12 were allocated to the Voyager program and redesignated Voyager 1 and Voyager 2.)

The mission objectives were to measure Mercury's environment, atmosphere, surface, and body characteristics and to make similar investigations of Venus. Secondary objectives were to perform experiments in the interplanetary medium and to obtain experience with a dual-planet gravity assist mission. Mariner 10's science team was led by Bruce C. Murray at the Jet Propulsion Laboratory.

The Mariner program was conducted by the American space agency NASA to explore other planets. Between 1962 and late 1973, NASA’s Jet Propulsion Laboratory (JPL) designed and built 10 robotic interplanetary probes named Mariner to explore the inner Solar System - visiting the planets Venus, Mars and Mercury for the first time, and returning to Venus and Mars for additional close observations.The program included a number of firsts, including the first planetary flyby, the first planetary orbiter, and the first gravity assist maneuver. Of the 10 vehicles in the Mariner series, seven were successful, forming the starting point for many subsequent NASA/JPL space probe programs. The planned Mariner Jupiter-Saturn vehicles were adapted into the Voyager program, while the Viking program orbiters were enlarged versions of the Mariner 9 spacecraft. Later Mariner-based spacecraft include Galileo and Magellan, while the second-generation Mariner Mark II series evolved into the Cassini–Huygens probe.

The total cost of the Mariner program was approximately $554 million.