The 1910 London to Manchester air race took place between two aviators, each of whom attempted to win a heavier-than-air powered flight challenge between London and Manchester. The race had first been proposed by the Daily Mail newspaper in 1906. The £10,000 prize was won in April 1910 by Frenchman Louis Paulhan.

The first to make the attempt was Claude Grahame-White, an Englishman from Hampshire. He took off from London on 23 April 1910, and made his first planned stop at Rugby. His biplane subsequently suffered engine problems, forcing him to land again, near Lichfield. High winds made it impossible for Grahame-White to continue his journey, and his aeroplane suffered further damage on the ground when it was blown over.

While Grahame-White's aeroplane was being repaired in London, Paulhan took off late on 27 April, heading for Lichfield. A few hours later Grahame-White was made aware of Paulhan's departure, and immediately set off in pursuit. The next morning, after an unprecedented night-time take-off, he almost caught up with Paulhan, but his aeroplane was overweight and he was forced to concede defeat. Paulhan reached Manchester early on 28 April, winning the challenge. Both aviators celebrated his victory at a special luncheon held at the Savoy Hotel in London.

The event marked the first long-distance aeroplane race in England, the first take-off of a heavier-than-air machine at night, and the first powered flight into Manchester from outside the city. Paulhan repeated the journey in April 1950, the fortieth anniversary of the original flight, this time as a passenger aboard a British jet fighter.

Isidore Auguste Marie Louis Paulhan, known as Louis Paulhan (French: [pɔlɑ̃]; 19 July 1883 – 10 February 1963), was a pioneering French aviator. He is known for winning the first Daily Mail aviation prize for the first flight between London and Manchester in 1910.