The siege of Antioch occurred in 1268 when the Mamluk Sultanate under Baibars finally succeeded in capturing the city of Antioch. Prior to the siege, the Crusader Principality was oblivious to the loss of the city, as demonstrated when Baibars sent negotiators to the leader of the former Crusader state and mocked his use of "Prince" in the title Prince of Antioch.



The Principality of Antioch was one of the crusader states created during the First Crusade which included parts of modern-day Turkey and Syria. The principality was much smaller than the County of Edessa or the Kingdom of Jerusalem. It extended around the northeastern edge of the Mediterranean, bordering the County of Tripoli to the south, Edessa to the east, and the Byzantine Empire or the Kingdom of Armenia to the northwest, depending on the date.

It had roughly 20,000 inhabitants in the 12th century, most of whom were Armenians and Greek Orthodox Christians, with a few Muslims outside the city itself. Most of the crusaders who settled there were of Norman origin, notably from the Norman Kingdom of southern Italy, as were the first rulers of the principality, who surrounded themselves with loyal subjects. Few of the inhabitants apart from the Crusaders were Roman Catholic even though the city was under the jurisdiction of the Latin Patriarchate of Antioch, established in 1100. This patriarchate would endure as a titular one after the Crusades, until it was dropped in 1964.